Depends on what I want to use the knife for. The edges will always whittle hair, whether the bevel has 400 grit scratches or 0.5 micron polish. They will feel different to the touch and cut very differently though. As for tools, I like my Chosera stones. I also use HeavyHanded's washboard system, a DMT XC plate, coffee mugs, and a leather strop.
I certainly can't claim to produce the best edges in the world, so I don't think I know the "best" sharpening method