I prefer synthetics for the simple fact that wood moves,(to quote a popular maker here on BF)even stabilized wood will warp,shrink or crack.
I've had three knives with some beautiful wood handles & all three developed cracks(even the stabilized).I have a couple others with more straight grained wood that simply shrank.
I've had no such problems with my G10,micarta,or rubber(Res C)handles.
I still order & buy knives with wood handles because it's just plain so much more beautiful,but like the beautiful woman,it comes at the cost of higher maintenance.
I recently bought a bottle of mineral oil for soaking my wood handles,so hopefully I won't have anymore issues with my wood.
I was using Ren Wax,but it doesn't soak in like the mineral oil will.
Proud supporter of JK Knives # 67,and all makers of hand crafted goodness.
It's better to have it & not need it than to need it & not have it! (guns & knives that is)