Pick the right tool for the job. I used to work exclusively out of reverse grip, and usually with a huge Strider tanto. I was looking for big, deep penetration. When I started to train more with folders, I found that they tend to work better for slashing and either de-fanging, or cutting the inside of joints to immoblize an opponent. How deep are you really going to penetrate with a 3-4" folder. I have found that I like the Commander for very rapid deployment, and I use it to slash and immobilise in saber grip. I tend to use the tanto bladed knives (Sofck, CQC-5-7) in reverse grip, and am looking for penetration. The CQC-8 is my favorite because it works well for everything (I can hardly wait for my waved one to arrive some day). I have been working on some pretty neat stuff with the P-Sark, and CQC-9 for LE work. I personally gear my training around very simple, dynamic techniques that I don't have to think about under stress. I use specific tools for the mission at hand. With that said-I carry a Commander more than any other knife.
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He who advances is sure of heaven-He who retreats of eternal damnation.