I find the Small slightly more difficult to open and close with my size large hands. I like it because it's more comfortable to carry than the Large, with enough blade for most purposes. Even though it's very compact it has nearly as much usable edge as some larger knives, like the Spyderco Para Military 2 for example. That said, if I was going to limit myself to one CRK it would be the the Large--it's really the prefect all around size, though it's big and heavy enough that I feel it in my pocket. These days I go pretty much 50/50, Small/Large. My advice: Get both, of course!