If I remember right: Back in the old days, the steel handles were tip down, and Spyderco went to tip-up only for the zytel/FRN models, for engineering reasons: couldn't put those original integral FRN clips on the pivot end. But the Spyderco default was tip-down. Many users actually found they preferred tip-up, though, so Spyderco couldn't keep just tip-down for everything but zytel models.
These days, I'd imagine that for collaborations, the designer chooses. Otherwise, I dunno, though if it were me, I'd usually default to tip-down for ball-detent models, tip-up for models that provide closing pressure with a spring.
I like tip-up better, not for speed, but because in a stressful situation, tip-up is more secure. In tip-up draw, I have all my fingers on the knife at all time; in tip-down, there is always a pinch-grip involved, unless the pivot is so loose that I can just wrist-flick it open.
Joe