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This would be dependent on build quality. The closer the tolerances, the less the actual hardware is keeping the knife together. On my ZT's for example, the standoffs are holding the knife together, not the hardware. The hardware hold the standoffs in place, if that makes sense. You could always loctite to be sure.
On the knife in question the hardware is the only thing keeping the scales together - it's backspacer construction without thread inserts. Do you think they would come loose on their own due to carry & normal use?