Dennis,
Both of my 420V knives are from DDR, and the EDC has seen the most use, so I'll just talk about it.
I haven't seen anything to make me believe 420V is fragile. I don't give the knife any special treatment, except for not cutting wiring or prying with it (stuff it shouldn't be doing anyway). Only time it's chipped was from the edge impacting the corner of a steel table I was working at.
I've had no problems with rust, even though I work in a hot, humid environment that contains alot of corrosives. The knife gets covered in grit, soaked in sweat, and all I do is rinse it in tap water, or blow it out with compressed air. I give it a blast of WD-40 every couple of days, and lube the pivot once a week or so.
It holds an edge well. I haven't tested them side by side or anything, but my impression from "use-between-sharpenings" is that it holds an edge about three times as well as the ATS-34 knives I've used. It's hard to reprofile. Not that hard to touch up. Only takes a minute. I use a Spyderco Sharpmaker, and use the corners of the white stones.
Like Will York said, Rc is around 57.
I could probably type another page about it, but time just ran out, and I gotta go