Not only is the holder not designed for such a weight, it seems somewhere between pointless and counterproductive, even if it would work.
When you're sharpening freehand, there may not be much of the stone in contact with the edge at any one time, but a larger stone will stay put better, and make it easy to use the whole width by moving things around.
All of those advantages evaporate when you're moving the stone with a guide rod, and I'd think the weight, and the lowered visibility, would make it much easier to use too much pressure and make mistakes at tricky areas like the tip.