Personally, I would be much more excited about seeing Buck offer some of their hunting knives in 1095 or 1095CV.
The Vanguard, like the 100 series knives, are designed to be hunting knives. Other Buck's like the Hood collabs, the Reaper, Endeavor, Compadre, and Selkirk are designed as full tang survival or all-rounder knives. In particular, they invite being used for chopping or battoning. (IMO, these knives would be more compelling and better competitors to Bark River, Blind Horse, Falkikniven, Enzo and others if they used a convex or sabre grind.)
5160 is most well known for toughness, not edge hold whereas 1095 is more known for better edge holding (while being plenty tough for this size knife).
I say, 1095 for hunting knives. 5160 for survival knives.