If you're looking at having a knife made, the more important thing is to find a knife maker you want to work with whose style, ergonomics, etc. are a good match for your needs, and then get their input into what the steel should be--as he or she may have experience with (or a source for) one but not the other.
If you're comparing a couple of existing knives (factory or custom), unless they're EXACTLY the same knife except for the blade steel, then it isn't worth your time worrying about--other factors will contribute infinitely more to how well it performs for you.
Proper heat treatment, the hardness tempered to, and geometry are the key factors in determining cutting performance for any steel, and the "I tried a knife in A2 and another in 52100 and I liked the A2 one better" type of comparisons are so ridiculously full of variables that have nothing to do with the alloys involved as to be all but useless. Especially in this case, as these two materials are in the same ballpark overall.
52100 is more suited to forging (especially since it usually comes in the form of a bearing or rod) and is more conducive to differential tempering if you should desire it, whereas A2--while it CAN be forged--tends to be used in stock removal making and a homogeneous temper.
Both will darken with use, both will pit quickly if you leave them covered in blood, both are reasonably tough and have good edge holding in a variety of cutting mediums (good abrasion/deformation resistance ) and you will never be in a situation where you have a knife made out of one of them which fails and you'll say, "Oh, if only I'd gone with the OTHER steel!" Well, you might say it, but it isn't true.
