The Buck/Mayo TNT is very cool, but I actually do think you can do better for the price, even if you do include titanium. That's different than saying it's not worth it, but I don't consider it to be a top value. Take the Skirmish or Mini skirmish, for instance. Framelock, titanium handles and S30V blade, roughly 150 dollars.
More important than value, though, is that you get the knife you *want.* I mean, if you can't afford it, then get the knife you need, but I'm certain the TNT will be capable of meeting your requirements if it's the genre of knife you're looking for.
Pay *very close attention* to quality control...I'm learning quickly that just because you pay 100-200 dollars for a knife is no indication whatsoever that it won't have "cosmetic defects." Ask newgraham.com to thoroughly check a few out and give you the best, though I know not of any defects in this knife.
Will you notice a big difference between that knife and a good 70 dollar one? S30V is a really great steel, I've just started using it myself, but I don't think it's that huge a difference over a good steel like VG10. I think that if you like a Benchmade D2 Griptilian or a Spyderco Centofante (VG10) roughly as much in looks and ergonomics, then no, I don't think the super high end knife will outperform them in any discernable way.
Mostly, you're paying for the titanium handles and S30V steel, which is going to be pricy no matter where you get it.
Hold the knives in real life, choose the one that has the materials you find acceptable (steel or handle material), good ergonomics and looks good to you. That might very well be a beautiful knife like the TNT. Mind you, you don't have to *buy* the knife in real life...just try.