For durability, I'd say my favorite scale material in the Vantage lineup is the FRN in the Select models. I have not been able to damage the FRN from and/or dropping it, whereas I have put sizable gouges into the G10 scales from the Pro and little gouges and dents just keep appearing on the Dymondwood scales on my EDC whenever I'm not looking.
As far as the factory blade grind is concerned, I've seen uneven blade grinds (as in asymmetrical and/or uneven on one side, like the OP described) in knives from every manufacturer at my local knife shop, from Buck to Spyderco and Benchmade. I don't even concern myself with the quality of the edge grind anymore, with the exception of how well the tip is shaped (I find it a real chore to reshape a factory rounded tip), since I'm just going to reprofile and put on my own edge anyhow.
On the other hand, I've been trying to find a NIB Vantage Avid with very good fit and finish and few to no defects, just to collect. I'd like to have a pristine Vantage Avid to compare my EDC Vantage against in the future, just to have a new stock item to compare my modified used item against. And due to the aforementioned issues, it's been very difficult finding one I would like to keep for that purpose. So if you intend your knife as a safe queen, then no you're not being nit-picky. But if you're EDC-ing your knife, then you might be being a little nit-picky - keep in mind that the Vantage line is a pretty good value, and something has to be sacrificed somewhere to achieve that.