I think it goes beyond the labels: Handmade, Custom, Hand finished to how the knife came to be and what input can be had to make it mine and do I even want it.
For example one of my favorites is a mid-tech Fiddleback Runt seconded by a custom Runt, although in reality they are the same knife (Runt), save the steel and what was done in the shop versus outside and the price is adjusted accordingly.
Another favorite is your EDC 01 and Hikers Backup. I think of them similarly as you made them from start to finish, except the backup I got to influence a whole lot more. Both handmade, but one is custom for me.
My Sebenza, essentially a knife born out of tolerances and computer engineering is anyones guess. Does $$$ invested in machines to achieve perfection downgrade Sebenzas to production, like a entry level Spyderco, SOG, or Benchmade? IMHO, nope, while they are mostly machine made and human fitted, the level of detail is that of craftsmen, so I categorize like handmade/custom.
I guess as long as the process is described and different levels of hand/machine involvement are disclosed and priced accordingly, I'm ok with all variations. When they're not, I am usually not buying anyway.
YMMV