I can't imagine it being very efficient with a scope, unless it's on a rest.
You have to hold with two hands to stay steady on target at all, the angle of the wrist area is much more awkward than a long-barreled revolver, you'll be fighting a lot of weight in an unconventional grip with a severe muzzle-heavy balance.
The gun unloaded weighs over 4 1/2 pounds.
It'd probably also be a nuisance even trying to mount a scope, have to be a long eye relief handgun glass & probably mounted with some sort of Scout rifle rail.
In my .44-40 Chiappa running 200 grain lead at a little over 900 FPS, recoil is very tolerable with one hand or two.
A .44 Mag may be uncomfortable to shoot at higher recoil levels, even with the weight of a heavy "pistol" and a scope on it.
You won't want the burro end anywhere near your face, the thing tends to come straight back & you'll lose teeth or bone structure.
Not necessarily trying to talk you out of it, just advising so you can think it through.
Legacy Sports sells a backpack rig for their Chiappa that might fit, but not with glass.
Bob Mernickle might adapt one for a scoped Mare's Leg.
Denis