I love my skyline. it is solid, light, and very thin. it it very versatile. I can carry it clipped to my pocket to be my main carry, or, if i want a larger knife as well, then it gets dropped in a back pocket. it is an excellent slicer, and is very easy to sharpen. the handle shape is comfy, if not a bit overly angle shaped, and between the flipper and the dip in the handle, it makes me feel very secure when cutting. Speaking of the flipper, i will say the the thumbstuds are basically worthless, and so if you want to open it with your thumb, then i would go for the persistence. I personally love the flipper, but everyone is different, so go with what you prefer. I do not own a persistence, so i am slightly biased, but i will say that the skyline would be an very good choice.
IMO, it all comes down to personal preference. go to a knife store that has both options, and ask to hold them. grip them, practice imaginary cutting, and generally make sure that you don't have a significant preference of the handle or opening medium of one or the other. if you hate the way it feels, then you will never carry it and it becomes a 30 dollar paperweight. I wish you luck and i hope you get a quality piece of hardware.