I love duffle bags. Easier to carry, stows better in car trunks and multiple ones can be mushed in together in corners and odd spaces. On airplane carry on, a medium duffle bag can be stuffed under the seat so you don't have to wrestle with the crowded overhead bins. I've got a large one that is a square shape with a zipper flap on top that is a dream to pack or find something in because the whole top zips open and flips aside. And the really nice thing about duffle bags, when we're not using them, they all get rolled up and stuffed into one big one so they don't take up a lot room on the basement shelf. One duffle bag holds the other several.
With both the better half and myself being retired now, we're traveling a lot. The 'ol lady likes to put her stuff in many small bags that are color coded. Hair products in one color nylon bag, under ware in another color, personal stuff like jewelry in another color, recharge cords former phone and computer in another color or type of nylon bag like zipper or draw string, and then they all go in one large zip open duffle bag, so when she's looking for something, she just zips open the big bag, and goes for the right color little bag where she knows the item is.
I love duffle bags. Makes travel easier moving from place to place every night.