I just bought my first real knives and my EDC one being a Spyderco Cara Cara G-10. ....What I want to know is 1) What should I do as soon as I take my knives out of their boxes. 2) Does my habit of opening and closing a lot harm the knife in the long run?QUOTE]
In reverse order.
2) opening and closing a lot does not hurt the knife.
1) YMMV but one of the first things I usually do is sharpen the blade, even if it seems quite sharp out of the box. When I look at most new blades under a 5x lens, I see fine grind marks. (I buy the less expensive Spydercos etc. I have no Byrds so I don't know if they also have such grind marks.) IMO these weaken the edge so that it does not retain its sharpness as long as if there were no grind marks. If I find grind marks, I sharpen the new blade until I can no longer see the marks using a 5x lens. If you do not know how to sharpen, a Spyderco Sharpmaker is easy and anyone can use it.
Whether or not you feel a need to sharpen immediately, as several have said, you should learn to sharpen.
Enjoy your new blade!