Eh, I thought about doing something along those lines, but I'm more of a user than a collector. Realistically, there's only going to be one or two combinations of handles and blade steels that are going to do it for me, and everything else would be a waste of money because they would just sit in a drawer. In addition to that, factor in the extreme expense and rarity of some variations that are disproportionate to the actual functionality of the knife (example: S30V Kershaw Skyline goes for 110+, but the build quality and functionality don't warrant the price).
I suppose that's a very utilitarian way of looking at it, and might be totally unrelated to the perspective of a collector, but that's just how I look at knives. No matter how many knives I get, I still end up paring down to he ones I know I can rely on. 0550, Gayle Bradley, Tuff Lite.