OK, the Skirmish is a big knife, with a 4.3" blade and with titanium hilt scales. The blade is of CPM S30V, as are the blades on the Spyderco Chinook II and the Manix. The two Spyderco knives use G-10 for their hilt scales with dual steel liners, skeletonized and nested in the case of the Manix in order to lessen the knife's weight. Both have what Spyderco calls a "Forward Lock Back", a lock back where the lock has been moved up the back of the hilt to a position where it is less likely to be accidentally unlocked during hard use. While both of these locks are very strong, the one on the Chinook has been made extra strong for its MBC (Martial Blade Craft) rating, since the knife was designed by close quarters combat specialist, James Keating, especially for his knife fighting style. It is, according to those who should know, extremely effective for that use. Finally, both are available with clips that may be placed so that the knife may be carried right or left side and tip up or down, according to preference. They weigh about 6 ounces each.
The Skirmish uses a very strong frame lock, as in the Chis Reeves folders It is not very ambidextrous. The clip appears not to be ambidextrous nor to be changeable from tip down carry. It weighs 6.43 ounces.
The prices are, at New Graham, about $116 for the Spydercos and $150 for the Skirmish. So, it comes down to a matter of price and preference. The Manix has a flat ground blade that many prefer, but I do not. I prefer the hollow grind on the Chinook, feeling that it makes for a stronger blade. While the blade on the Skirmish is hollow ground, it is also a recurve style that I have found very difficult to properly maintain. I also find the G-10 material easier to retain in wet conditions than titanium as well as finding the shape of the Manix and the Chinook rather more egonomic, at least for my hands. So, my choice is the one that I have, the Chinook II. If I didn't have a Spyderco/Terzuola StarMate that I like better, I would probably use the Chinook II as my EDC when away from my federal office.