If the materials your knife is made of can stand hot water (steel, micarta, G10, etc) just a trip through your home dishwasher is sufficient. Use the temperature boost button (about 150 deg. F, or 65 deg. C. for those outside of the US). This temperature combined with the high pH (caustic) nature of dishwashing compound will kill about anything you could be worried about. Natural materials probably need a chemical treatment in a weak antibacterial agent. Remember, the death of microbiological cells is a time/temperature/concentration relationship. A weak sterilizing solution at high temeprature or long contact time is about as good as a high concentration for a short time, or cold.
As far as radiation is concerned, it is only legal on spices, as an antisprouting agent on some seed products, and as a pasteurizing agent for meat. That means a surfact treatment only, not deep tissue penetration. There are side effects of radiation treatment on fresh meat, like oxidized (rancid) fat flavors. We will get there but it will take a while.
Bruce Woodbury