Here's what works for me,
When you're designing try not to force it, think about what you like in nature, architecture, women :^ ), cars, artwork, whatever helps you visualize a shape keeping the basic knife function in mind, it has a cutting edge. I happen to like curves on women, cars and things so my knives usually have curves in them, I also like nature and texture, some people like twiggy, straight and smooth. Ideas come at any time, when they do it's important to draw them out right away, don't worry how they look right now you can refine it later.
Most every knife that I make starts out as a scribble, usually on a piece of scrap paper in the middle of the night with a bunch of notes around it. Every time I get an idea for a knife I draw it out with notes explaining what I was thinking about at the time because my scribbles usually look like an unintelligible preschool stick drawing. When I'm wanting to make a new knife I look through these sketches until I see something that I want to try. Next it's time to get out the ruler, french curves, pencils, a good non smear eraser and regular no line paper, I've tried graph paper but all the little squares gets me crazy. A copier is helpful but you can use a non erasable pen for your reference lines instead.
Determine how big you want the knife to be, for example a 9" over all length fixed blade with a 4" blade and 2" at the widest point of the knife. Using a t square or measure from the paper edges draw an accurate rectangle, in this case a 9" x 2" rectangle, next draw a line lengthwise down the center so you end up with 2, 1" x 9" rectangles stacked on top of each other. Since this will have a 4" blade draw a vertical line at the 4" mark and that's where your guard/bolster intersects the blade. I usually make a few copies of this grid so I can try different variations of the original sketch, I make copies of this grid so I can erase many times and not erase my reference lines. The grid lines help me keep everything lined up like the blade tip above, below or at the knife center line, on some of the variations I go outside the grid lines, especially the handle butt or guard. Keep pencil drawing variations until you're happy with one of them, make a copy and cut it out. I use spray adhesive and glue the drawing on a piece of kydex, cardboard or something that's stiff enough so I know how the knife feels in my hand. If no more adjustments need to be done I'll use this pattern to transfer on to the actual blade and handle materials.
Dave