I quickly modified a couple of pictures to help explain the handle points a little better: the blue lines indicate contact between the handle and hand during a normal grip, also being points of exaggerated pressure during forceful cuts. The Red-line indicates a point of reduced or absent contact between handle & hand.
A straight spine focuses pressure on the muscles groups south of the 'pinkie' and between the thumb and forefinger, and forces the hand flatter against the spine. The RMD's curved spine allows this pressure to be more evenly distributed across the hand without forcing the hand to flatten-out as force is increased.
Now, the fact that the GSO-5.1 handle is laterally thicker in the palm is certainly beneficial, a trait that the RMD handle would benefit from (or rather the user would benefit), but the hand is also contoured vertically, and in this case the vertical contours are key.
Here is the shape of the GSO-10 handle - note how the vertical contours fit the hand: