I have both. Kind of hard to choose. If you've got big hands, I think maybe the Laser Strike. The handle on the 4 is not what I would call overly generous. I have 2 of the 4s. They are very classic knives though and would be equally at home, IMHO, on a hunt, in camp, in the bush, and strapped to Molle gear on a deployment. I think the Laser Strike would not function quite as well as a hunting knife. The handle on the Laser Strike, while large, is odd. It is by no means uncomfortable...just an odd shape. I cannot say it is a good looking knife but it feels very good in the hand. The 4 has a classic look...if you care.
Both are proven winners with lots of people declaring the Laser Strike their favorite ESEE. I like mine a lot that's for sure.
Tough choice. You'll end up with both. If you want a classic "can only own just one" knife, that'd be the 4 for it's ability to serve the hunter.