In many opinions, the best mix is O-1 and 15N20. They have closely matched HT and working specs. They weld together quite well.
If you aren't experienced with the process, start with three 4" long pieces of your metal - O-1/15n20/O-1. 1/4" O-1 and 1/8" 15N20 make a good mix. Weld the ends together with the TIG/MIG/stick and then practice forge welding and drawing the piece. When it is drawn to twice its length, hot cut almost through, quickly wire brush clean, flip over on itself, flux lightly and re-heat,...and weld together again. Repeat about six or seven folds. This will make a simple random pattern 196 or 392 layer bar for a blade.
If you have forge welded before:
Cut four 4" long pieces of 1.5X.25" O-1 and one that is 8-12" long.
Cut four 4" pieces of 1.5X.125 15N20.
Clean up, stack, clamp, tack weld ( stick, TIG, or MIG). The long bar goes in the middle, and provides a grip for the tongs. Z-box or U-box tongs are the best for the task. Wolf jaw tongs are great for handling the billet when there is no handle attached.
For knife fittings, either draw and stack the above billet two times, to get 36 layers, or do that and then twist the billet to get a bold curved stripe guard and butt cap.
Whatever you do, read up on forge welding and drawing damascus. If twisting, the billet has to be forged square and solid, then octagon, then round, then twisted. After the twist, clean up on the grinder and forge back to a bar.