First you need to narrow down what KIND of folder you want to make. Although much of the techniques, tips and tricks will translate from one to the next, we can get a lot more specific with resources based on the kind of folder you want to start on.
Lockback?
Linerlock?
Framelock?
Slipjoint?
Friction folder?
Balisong?
etc.....
A lot of guys will start with kit knife, or taking one apart and recreating a similar pattern. A CAD program can certainly help refine a design and get a very accurate idea of how parts will fit and move together. Places like USAKnifemaker sell plans for various styles of folders, and will often provide a parts list so that you can order everything you need.
Whatever you choose to make, start simple and work slow.