Actually it does make the lock weaker to heavy compressive force. I don't think it affects reliability though, which is usually a much bigger concern.
When a framelock is under heavy pressure it will either buckle at the cut out or sheer off part of the lock-bar. This is one reason steel framelocks can sometimes be better, though Ti is very sticky when it rubs on other metals, so it should be less likely to release accidentally.
If I remember correctly "heavy pressure" is between 100 and 200 lbs, depending on the knife. Plenty strong for what the average knife goes through, but don't expect it to hold if you want to hang off it or something silly like that.