No choice but to open them one-handed. I can't really use my left arm/hand much. V.A. Doc said I had probably about 20% use of it when I got out, and it's gotten a bit worse over the last 13 years from other surgeries.
I have 2 GEC knives:
Half Congress in stag
EZ-Open in jigged brown desert sand bone
I also have been carrying a Case serpentine jack lately.
How I open them varies. If I can get a good pinch grip on the blade, I'll hook the end of the knife opposite the pivot end under something , then pull up. Sometimes if the pull is easy enough I can hold the knife between my thumb and middle finger, while pulling up on the blade with my pointer fingernail in the nail nick. Not real quick, and most times I have to stop halfway to reposition things, but it works.
Half-stops can be scary at times for me. As I bring the blade up and it nears the half-stop, the blade will spring into position. That sudden movement can make the knife difficult to hang onto in the awkward way I open them.