Describing a knife as "unsharpened", by itself, isn't worth much. Because a knife could have been extensively carried and used without being sharpened by the owner, but still appear to have it's factor edge.
However, if a knife is described as "never used, never sharpened, original condition", then I could see that as a selling point.
As far as knives being sent back to the manufacturer for re-sharpening, I wouldn't necessarily see that as a depreciating factor. Because the manufacturer is likely putting the same edge on the knife that it originally had. And if the manufacturer puts good edges on their knives, I'd say that's a good thing.
The only way I would see it as a bad thing is if having the knife re-sharpened by the manufacturer is the result of the knife being used, and the seller advertises the knife as "unused". Or, because every sharpening takes off some amount of steel and takes the knife further away from "original condition". How much steel is removed is determined by how dull the edge is, and by the skill of the one doing the sharpening.
As far as how to tell if a knife has been re-sharpened, you would either need to know what the original edge looked like, or, you need to trust the seller (buying knives from people on the internet requires a lot of trust). But if the knife were re-sharpened by the manufacturer, or by some other professional who did a really good job, then you might not be able to tell, especially if the rest of the knife looks new.