Delrin, in it's current form for knife handles anyway, is very resistant to cracking. On newer knives I have with it, the stuff is practically bulletproof, and very flexible. BUT, older knives with older versions of Delrin may be different. Delrin (as officially named by Dupont) has undergone about a zillion formulation changes since it was invented back in the '50s. And even now, there are a lot of different recipes of Delrin, manufactured for different purposes. Some versions are formulated for better shock-resistance, some for higher strength/rigidity, others made for high-finish/low-friction qualities. And there are other synthetics very similar to Delrin, but trade-named differently.
Some older synthetics were more vulnerable to hardening & cracking, due to exposure to sunlight or harsh chemicals (solvents). A lot of older synthetic-handled knives kept in display cases, over many years' time, will show fading/warping/cracking issues on the side that received the most sunlight.
As mentioned, bone especially will crack pretty easily. It's very hard & rigid, and won't 'flex' as much as would be ideal for use on a pinned handle, where the pins move in response to stresses placed on them (such as with the anchor pin for the spring). And the drilled holes for the pins can introduce additional weakness, if the drilling itself starts a crack or chips the bone, or if the holes are drilled too close to the edges (too thin). I think a well-designed and constructed knife would allow for some movement of the pins within slightly oversized holes in the bone or, better yet, make sure the pins are sturdy enough and well-anchored in the liners, so they won't move at all. Some knife frames also flex or bend, as a whole, which can create stresses on the scales.