Another trick, if you're trying to drill all the way through a long block- fix a point onto your drill press table for a center, sort of like a tailstock (i.e., clamp a drill bit or c-sink into your vise point up, etc.) then, with the centers of your hole marked on the block ends, set one center on the point, drill the other center from the top- then reverse the block, set the drilled hole on the tail center, and drill from the other side. The holes should meet perfectly in the center.
This can also help if your drill press doesn't have enough travel to drill all the way through. Or, you can drill as far as the press will travel, then retract the piece up along with the quill and put a block on the table, then drill farther. This would work with an aircraft bit.
Please disregard all of the former if you know it already, or if it doesn't make sense to you.