Interesting idea, a larger Mnandi. This thread had me get out my small Seb and Mnandi and handle each. The small Seb has never fit my hand well--the last two damaged/arthritic fingers on my right make three-finger grips difficult and I also find I need to shift the knife considerably to close the frame (more correctly, integral) lock. The Mnandi is more of a two-finger grip with the butt in the middle of my hand, opens easily with a pinch grip, and closes like a dream with the full lock-side scale rendering the knife more like a liner-lock.
I have lots of larger, beefier knives that fit me well and get lots of carry, but, yeah, the slimmer knife thing works too. I have an Al Mar Eagle Talon in cocobolo that handles well and carries in a pocket slip like my Mnandi, though it is considerably larger than mid-sized. As it doesn't seem likely we'll see that larger, mid-sized Mnandi, anytime soon or ever, maybe an Al Mar Falcon (3.15" blade) would give a sense of what our hypothetical knife might be like--differences in deployment and lock notwithstanding.