Any metal to metal will wear out both parts where they touch eventually.
I've seen Buck 110's on cops belts [ not recently ] that had been abused as prybars, ice picks, cutting metal with the edge, you name it, these 110's aaw it over 20 years.
The lock was worn out on most of them, the edge was a butter knife, the tips were all broken off, they had surface rust in spots, etc. etc.
There was lateral play galore as well on all of them from wear.
These were not carried for 20+ years, they were used continuously and roughly in all kinds of weather with nary a thought about it.
I do believe a few of my lockbacks will wear out, they are being used daily and if I continue to carry them and use them this way, I expect by taking care of them, unlike the lockbacks above, I should get 20+ years out of say, a Chinook, whose steels are better, whose heat treat is better, whose polerances are better, etc.
Perhaps it is the MPC, but more likely the ER Fulcrim 11D I now carry that will wear out and become unreliable. Thats fine with me as it can be fixed or replaced with another or another knife all together at that time. Of course I'll be happy to replace it when it wears out. I'll be in my early 70's
Lockbacks have proven to be hard use easily maintained [ or more likely not maintained ] folders that have a good strong locking system not prone to failure easily.
If lockbacks were prone to be fragile, the buck 110's would never have become the officers knife of choice during the 60-70' era.
Lockbacks have come a long way since the 110 was made. I have no fear of any of mine wearing out before I do at this point.
Brownie