Well, I'm not gonna lie... If my fiance was not an RN, and if she didn't love me unconditionally (still trying to figure out her logic there) then this would probably not be happening.
I think the biggest things are don't screw with the tax man, and make sure you understand the legalities involved. As said above, a good cheap accountant is very important, unless you are naturally gifted with that type of thing.
I think many makers have a "calculated risk" period where they are just getting started, and not quite above board yet. Make sure this period is absolutely as short as you can manage.
If you want to work from home, you most likely will need to live in an unincorporated area that has very liberal views on zoning, or look for a property that is near a business area and was grandfathered in to combo business/residential zoning.
Another option is to have (or make) a friend that owns their own shop and is willing to sublet, so that you can be on the up-and-up while you save for your own.
Make sure you count each and every expense and KNOW what you really are making on each sale. Save your reciepts, even if you just throw them all in a box, it's still better to give your tax guy that, instead of a wild guess that may or may not get you in trouble with the tax man.
There are many other aspects, but I think the ones above are the ones that can land you in jail or very hot water, so I would say they need to be addressed before anything else.
Lots of guys who do hand-heavy activities are musicians, too. I was a luthier before I started making blades.
That's a field to never go FT in. I made that mistake. I hardly even play guitars anymore, I just pluck some bullshit to make sure all the frets are good, and the electronics work, and back to the case.
Musicians are also ridiculously flaky (and notorious) for nonpayment.
I had a somewhat similar background, I built my first guitar long before my first knife. I've been playing bass for about 20 years, and the extra hand strength definitely doesn't hurt, especially when hand stitching a sheath. I also have been tig welding for most of that time, and excessive heat on the fingers hasn't stopped me yet.
