What knife (or knives) are thinking about, specifically?
If you're talking about a "tactical" folder, an asymetrical grind is probably a comprimise between control (symetrical) and ease of sharpening/manufactur (chisel). You'll often see this on partially serrated knives. I know Kershaw and CRKT do this a lot. I imagine the reason these manufactures do it these ways is to maximize control. An entirely chisel-ground knife of that type (all-around use pocket folder) would lose some of its usefulness (read the post above). If the serrations remained chisel-ground (which is how they usually are), but the plain section was symetrical, the blade would make 2 very seperate cuts. Having an asymetrical grind lessens the gap between cutting planes.
For unserrated folders, I'd imagine it was done simply for ease of sharpening. The Surefire Alpha is asymetrically ground. Emersons are (mostly) chisel ground. These knives aren't really intended for "every day" use. Often Emersons that are used for daily tasks will eventually become asymetrically edged simply because of the method required to sharpen them. 99% of the sharpening is done to the normal edge until a burr forms, then the other edge is touched upon to remove the burr. After much use, it's likely that the opposite side will become ground some itself. This happened to me with a couple Spydercos. They are no less dull than they were before, just the "factory" edge is long since been altered.
EDIT: OK, my reply got crossposted with your clarification, but I'm still not sure what you mean. A specific example of a knife would help.