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Spyderco's method definitely works.Spyderco in general, and Sal Glesser in particular, are pretty transparent about their business practices. I may be misremembering, but I believe Sal stated that their MSRP and MAP pricing are formula driven rather than pushed to what the market will bear, which is a damn decent way to do business. He may have even given the specific profit margin they look for on knives, but I don't remember exactly.
I suspect other companies do things differently based on their overhead.