No. There are two issues at play, the sharpness of the micarta, and the nature of having a pommel flare that curves upward toward the palm. The part peter was talking about causing blisters is mostly the sharpness of the micarta, which can be rounded by sanding.
However, the pommel swell will still come up and hit the wrist/palm on the downstroke. this is most noticeable when you grip downward. in order to avoid having the pommel swell come up and hit your wrist, you have to keep it slightly angled so it comes up past the wrist on the palm side.
When you grip it from the center the pommel swell isn't that big of a problem, but when you grip it farther down:
that pommel swell becomes much more noticeable. The only way around this is to lessen the upsweep by taking off metal like the picture in my previous post with the red line on it. my understanding of how pommel swells interact with the hand is based on past experience with khukuries rather than the kz2, it is inherent in the khukuri handle design. The kz2 is basically a traditional khukuri handle shape, and thus has some of the inherent flaws in that design. I think peters modification, where the palm swell is continued on it's downard slope so that the rear lanyard hole is removed is an ideal solution. It would make a handle shape that is very similar to the older ergo handles, but much improved. You would still get the long handle for multiple grip positions and the wide curve/berth for wrist snaps, but without the pommel flare in the wrist problem.
In a normal or choked up grip, you probably won't notice it. It's a traditional shape that is good as it is, it would just be more versatile with the pommel flare clipped off on the palm side.