In an ideal world, a well made lock should be all you need for a secure knife, no matter the configuration.
Liner locks are fairly easy to make, but one must get the locking ramp and the liner just right. Liner thicknes doesn't seems to matter as much. I've seen the Spyderco Military and no matter how hard I try (short of using a hammer and vice) it won't budge. Failures usually occurs when the liner slips (I've done it to a folder that it slipped) or at the best case, the liner itself fails under the pressure. I don't know whether you would have detached fingers though.
Lockbacks are also fairly easy to manufacture, and usually found in traditional folders and Spydercos (and other companies) Spyderco lockbacks have moved the release up to about the midway of the handle, length-wise, and with their "intergral choil", usually it's fairly easy to close. I wouldn't know exactly how a lockback would fail, but if the pins holding the lockbars are not done well, they might fail.
Axis and compression lock should be fairly hard to make them fail when they are made properly. If they fail, they would likely blow out the stop pins.