In depends on what you want to do in the future with what you're loctiting. I suggest you read on the Loctite's site what it would take to remove the loctite. I think both Blue and Red loctite require heat application in order to unloctite it (or strong enough torque). If you're going to use it to make a screw secure and it's just holding like a scale to the blade handle, for this purpose, I use Purple loctite. It won't unscrew by itself but I can still take it off easy enough without having to apply heat. This is what I use.
Some other things I've heard that work is grease on the threads (perhaps it's because you can torque it more securely) or those pipe thread tapes.