I have medium-sized hands and not a lot of meat on 'em. I usually prefer magnum handles. I can't think of one of my Busses where I prefer the standards, though I like them just fine.
I used to be a die-hard canvas micarta lover, but lately I've been leaning towards the G10. I like that canvas micarta is made from...canvas. The Busse finish is extremely grippy with no polish and lots of exposed fibers on the handles. You can oil 'em up if you want better coloring, and they feel really good in the hand.
The reason I'm liking G10 is because the coloring is so good, and the way the Busse handles are cut I don't feel there is any issue whatsoever with getting a secure grip. With other knives that have polished handles I still worry about this, but really I think polished G10 and polished micarta are almost the same in feel.
I still don't really like that the G10 has fiberglass in it, but that's a personal thing.