What I do is first get pretty precise about how I'm indexing the angle. On my 0777, for example, I split the yellow dot. It's a bit harder for my girlfriend's Delica since it was already profiled at 16 degrees (32 inclusive), so a bit harder to hit exactly.
With the indexing in place, I first strop the blade on leather to see if it's just a slightly rolled edge. Sometimes that will get me another week of use before having to break out the stones.
When I do break them out, I like to start with 400 and work my way through the set to 1,000 and then strop with leather. However, this is with knives that I have personally sharpened and that I sharpen regularly.
In one instance, I went back with just the 1,000 stone to reset the burr so I could strop it properly, so I think we need to be crisply aware of the actual condition of the blade.
Oh, and the Edge Pro guys recommend starting with the 200 grit stone, which is perfectly fair. Only when reprofiling a factory edge (or a fudged up one from someone else) have I had to resort to the 120 grit stone.
Since I'm a cubicle dweller, my personal carry knives rarely get much use. My girlfriend is a vet tech and she is constantly cutting cotton bandages and cardboard with hers. So, I really have to get smart about keeping hers razor sharp and she's getting good about letting me know when it isn't quite as sharp as I want it to be (which is "slice your hand open and not feel it" sharp). She doesn't cut zip ties with it anymore (thank goodness!) so we aren't seeing edge chipping anymore. I got her some dykes for the zip ties. This is as "heavy use" as I have exposure to, short of the vet's hoof knives, which I tried my hand at, but the Edge Pro isn't the right tool to sharpen them.