I've done a bit of welding to tool steels, though not to 52100.
Welded areas experience localized yielding as they cool and shrink. The problem, especially with air hardening steels, is the welded zone has low ductility so it cracks. Preheating the work piece addresses this problem through a few mechanisms.
Sometimes you have to use a filler material of the same base materials such as building up a mold. But if you don't need that, I have found that stainless filler works more reliably.
You will want very clean joints to hedge your bets against cracks, and I find it better to use high heat and move quickly. If MIGing, short bursts with high power do the trick.
Some "unweldable" materials, such as cast iron, are welded with a very high nickel filler.
If you run into trouble I'd be happy to TIG it for you.