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I suspect there would be more chance of the heads damaging the G-10 than the tips scratching the blade, but it's possible they might. Given that the liner is relatively thin, they may be long enough to thread all the way into it with the clip in place. It would be easy enough to remove the clip, screw them back in with the knife open, look inside the handle, and remove them again if they're protruding through the liner.
Yes, I'm saying it would be fairly easy to screw one or more of them in tight enough to damage the G-10 directly under the screw head. The resin used for CF and G-10 chips fairly easily. It can almost be knapped, which is one reason the thick resin coat on "glossy" CF handled knives often has fish scale chipping around one or more screws/rivets. On G-10 handles, the "waffle weave" surface texture is straight resin, so it is fairly easy to damage. I've seen G-10 handled Spydercos where, if you moved the clip to a different set of holes, the G-10 at the original clip mounting site was scarred from the clip. Leaving the screws less that tight may solve that problem, but then there's a greater chance they'll eventually fall out.
I'd say somewhat less resistant. I don't carry G-10 knives, but I've seen plenty where the textured surface was worn smooth in spots from "carry wear". Have been carrying a peel ply CF Stretch on and off for a couple years, and the peel ply texture still seems to be about the same as on a brand new one. I carry it loose in my back pocket and while I never put anything but a knife back there, the knife does get rubbed against the fabric under pressure quite a bit.