Yes, it can be opened easily one-handed. BUT, it is not ambi-dextrous one-handed opening, as the liner is higher than the frame on the other side, and therefore it is extremely difficult for me to open with my left hand. I suppose I could grind it down, but at the moment I don't have the tools, time or inclination. It would also damage resale value - but I have no intention of selling, so I will probably get around to doing it sometime.
I had bought it in the belief that it would be possible to open it ambidextrously, as I am left handed, but can use either hand for opening a blade. I can only use one-handed opening with my right hand.
It is a lovely little knife though, and even people who hate knives still think it's a beauty. I have the box elder version - although not as good a grain as I would have liked i.e. a bit plain compared to some box elder grain I have seen.