The two BEST plastic (Zytel, glass reinforced nylon) knives are the Cold Steel Delta Dart and the A.G. Russell CIA Letter Opener (the original).
The reason for this is because non-metallics, especially of softer plastic like zytel, are stabbing weapons and stabbing weapons alone. You cant cut flesh with them, so you want the blade to do as much tissue damage when thrusting to hit vitals as it possible. The triangular shape of the Delta Dart and the unique cross section of the heavily fullered CIA Letter Opener leave nasty wounds, and both blade shapes are strong, and dont experiance tip deformation easily.
As cheap last ditch tools they cant be beat. You may never need them, but the one day you intuition says "carry this" - it could save your ass.
Some will say the Delta Dart can be cut where the blade meets the handle, so it can be snapped off inside someone - but this is more an assassination technique than a real world defense technique.
The CAT tanto has too fragile (soft) an edge and point to do much at all - and its too large to carry easily for something that cant cut. I found it best to grind it down and make a trainer. Other "CIA Letter Openers" and the Lansky "The Knife" are either too thin, and will bend, or experiance too much tip deformation just sitting around to be ones I really like.
Above and beyond Zytel is G-10, or the G-10 like composite Mad Dog uses. This will cut on a EXTREMELY limited basis, somewhat better if it is serrated - but still, its a stabbing tool - just tougher than Zytel, wont deform on a single stab.
Above that is Carbon Fiber - carbon fiber WILL take
an edge that can make four or five nasty gashes in meat before its dull - which gives it some added advantage over other synthetic materials. The reason it will cut like this is because fibers along the edge seperate, causing a micro-serration effect, like you can get on steel. This type of edge can be restored with an emery board or sand paper.
Carbon Fiber can be serrated, and
the serrations will keep ripping tissue long after their micro-fibre-serrations are worn off. And it can also be used to build larger knives as you can see.
Carbon Fiber is also extremely strong, and light-weight at the same time.
In my work making blades from plastics, G-10 and C/F, I've found C/F to be the best, and I work with it almost 100% of the time, unless a customer requests something different. Its what I would reccomend someone to use when they find a maker willing to make them a non-metallic.
The only thing better than that would be one of the all ceramic knives from Mad Dog, but they arent made any longer - and the ones that were sold to civillians had metal inserts in the handles (ont he rubber handled ones, this wouldnt be a problem, peel the rubber off, remove the metal, and then stick the handle in Dip-It or something.)