With regard to ergonomics, the only thing I might like to see refined is the jimping on the liners, alongside the backspacer and near to the back (non-pivot end) of the handle (the jimping at the choil is more to my liking). At times, it can seem a little bit coarse in bare hands. Wouldn't mind it if it the 'teeth' were just a bit smaller (finer pitch). With gloves, it's probably just right. Overall, I like mine a lot. It's a great knife.
Edited to add:
For some reason, when I first saw this post, my mind immediately went to "what's your opinion regarding the Manix2?", as opposed to the BBL specifically. My Manix2 is the only Spyderco I own with the BBL, I have no experience with other models. That being said, I have no complaints at all about the lock. It's very strong, and backed by a stout spring (I like it better than the spring on the Axis-lock Benchmades, which to me is a little on the weak/soft side). It may take some 'conditioning' on the part of some users to get used to it, but it's reassuring in it's stoutness. Inspires confidence that it'll never release accidentally, which was my biggest concern about the Axis Lock. I'm not slamming Benchmade, I have a couple Axis Locks and I do like their designs. But, I've always wished they'd beef up that lock a little bit.
) journey with the CBL and the Manix 2. I bought the S90V sprint and was initially impressed but decided the whole thing didn't really agree with my lefty-preferred ergo perspective. However, I bought one of the 154CM "standard" models before I reached that point. 
