This is a great topic and I hope it generates some good discussion.
I'm assuming by "making it" you are talking about the ability to sell your knives and
be profitable. I have thought about this but from the viewpoint of someone that is wanting to sell knives to support a hobby(habit

). So take this fwiw. Maybe there should be two categories; Usable and collectable
If you design a knife that you believe is a good user, maybe it will be a popular knife. It would be a good idea to pattern that blade so that when someone says, "I really like that knife...Do you have any more with this handle, this steel, etc.?" You can then whip out another one without thinking about it too much because the design part is done.
The collectable market should probably be approached slightly different. Isn't that more of an artistic market so therefore the work that you put into the knife is more detailed and unique. This kind of knife would command a higher price and demands more from the maker. It could be a pattern but since it is artsy it is more likely to be the one-of-a-kind, higher end knife.
If I made a knife and, say....Ken Onion...made the exact same knife but mine was better

, which knife is the best investment? So, now we are getting into the importance of name recognition and what that brings to you in increased or diminished sales potential.
I think it is probably wise to make more "pattern knives" at affordable prices so that you can get a return on your investments in supplies. Make some of the higher end, one-off, artsy knives to show off your skills and have available to sell to the collector/investor.