I remember reading posts cautioning against getting a full-size Rukus, Skirmish, or Manix for EDC. Too large in the hand, they said, too thick and heavy in the pocket. You will cry bitter tears and wish for a smaller slimmer lighter knife while the rough scales stab your tender thighs, that sort of a thing.
With the Manix anyway, I find none of that to be true. I haven't handled the other two. The Manix displaced my much beloved Endura as EDC. I carry it every day clipped in the front pocket of my cargo pants, and I honestly can't feel it there, just as was the case with the Endura. My work requires me to crawl around on my knees from time to time, but this too has brought no discomfort, at least not from the knife.
At this point, I don't see myself going back to a smaller knife for EDC. The Manix feels great in my hand, is totally unobtrusive to carry, and it has the deeply satisfying feel of a full-scale tool, no compromises, rather than a 2/3 scale lightweight replica.
Perhaps a small person who has to wear paper-thin slacks to work will find the Manix uncomfortable. I find it most excellent. Oh yeah, it cuts very well, but that goes without saying for a Spydie.