The 250 will set a bevel but it probably isn't the right stone for it as it may take a lot longer, just depends on how much metal you want to remove. Keep the pressure light, take your time and you won't have any problems with the stone wearing. I came up with the 80 grit to fill that void where the 250 isn't aggressive enough. You can make the jump from 250 to 1100 if your angles are perfect using 10-15 strokes on a 3" blade, but it is stretching it to the absolute limit of grit progression. I myself would rather use the 650 and do the last few strokes with no pressure to reduce the scratches left by the stone. The scratches won't be as fine as the 1100 but noticeably finer than a standard 650 scratch. I find I often start with the 650 when sharpening my work knives, the 1100 just isn't coarse enough for this initial sharpening IMO unless you use micro bevels.