They come that way from the factory-
right handed because that is what most people probably need.
tip down because that is most efficient.
People have different carry needs and switch the clips to left-hand and/or tip up as they desire.
But please if you buy the knife and don't know if you will keep it or not, it is better to not mess with the clip. I saw a PM2 sprint for sale on the exchange recently- the seller said he had never carried the knife but had switched the clip. Switching the clip probably cost him $50 on the sale of that knife. I refuse to buy a knife that has had the clip switched because I read about such a high percent of people that strip out screws doing this. If it's your knife and you intend to keep it and use it, switch the clip as you wish. You can buy reasonable tools for manipulating the screws at large stores such as HomeDepot and Lowes and they seem to work well enough for the PM2. Some people have had problems with the thread locking compound on the foreign Spydercos and you might need higher quality tools for them.