I'd be really careful with acetone concerning any kind of plastics. I use it fairly often for cleaning, degreasing and as a paint solvent. I have accidentaly destroyed numerous synthetic things with it, including clothes. Once I even glued (or melted, basically) my computer's mouse to the mousepad with an accidental spill.
I don't remember my chemistry at all really anymore, so I can't say about the types of materials it eats away easily. At least ABS, styrene, PVC, acrylic, some PE-plastics (though I buy mine in a PE-HD bottle) and polycarbonates are in the danger zone. If it wouldn't be possible to test the handle material in long term, I would try to seal off the handle as well as possible, even from the fumes. Of course, if the resistance can be confirmed (from the manufacturer?), no problem there then.
Acetone evaporates real easy, and it's really flammable, so that's the biggest reason for caution. Short term, it isn't that dangerous for ones health externally, makes your skin dry. The fumes make you feel slightly woozy and maybe give you a headache. Long term and in large amounts, iirc, it can inflame your organs and cause kidney damage. If you were able to drink it (whitch I sincerely doubt) you'd probably pass out and wake up hung over with a flammable sweat. I also wouldn't relieve myself near an open fire.
Anyway, I tried to remove the coating from my Glock field knife with acetone. Didn't do much good interestingly. I used a rust remover gel (phosphoric acid, less than 10% conc.), which worked decently.
It'd be real interesting to find out what kind of resistances to different chemicals all the coatings used nowadays have... I wouldn't have figured that Busse's coating is so susceptible to acetone.
Apologies for the ot babble and the unwieldy use of English. Not a native speaker
